Protein Details: Aquaporin Z

Protein ID

ICDB_Pro_0657

Protein Name

Aquaporin Z

Gene Name

aqpZ; bniP; b0875; JW0859

Organism

Escherichia coli (strain K12)

Length

231 amino acids

AlphaFoldDB

AF-P60844-F1-model_v4.pdb

Function

Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.

Sequence

MFRKLAAECFGTFWLVFGGCGSAVLAAGFPELGIGFAGVALAFGLTVLTMAFAVGHISGGHFNPAVTIGLWAGGRFPAKEVVGYVIAQVVGGIVAAALLYLIASGKTGFDAAASGFASNGYGEHSPGGYSMLSALVVELVLSAGFLLVIHGATDKFAPAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTAVAIFQGGWALEQLWFFWVVPIVGGIIGGLIYRTLLEKRD

PDB Structures

1RC2 2ABM 2O9D 2O9E 2O9F 2O9G 3NK5 3NKA 3NKC 8H1D

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 20: "Involved in tetramerization or stability of the tetramer"; SITE 43: "Selectivity filter"; SITE 174: "Selectivity filter"; SITE 183: "Selectivity filter"; SITE 189: "Selectivity filter"

Disease

Location

DOI ID

10.1074/jbc.270.49.29063; 10.1080/15216549700202061; 10.1093/dnares/3.3.137; 10.1126/science.277.5331.1453; 10.1038/msb4100049; 10.1128/jb.181.14.4193-4197.1999; 10.1006/jmbi.1999.3032; 10.1073/pnas.161299398; 10.1006/jmbi.1999.3031; 10.1093/emboj/18.18.4981; 10.1126/science.1109730; 10.1371/journal.pbio.0000072; 10.1046/j.1365-2958.2000.02016.x

RefSeq

NP_415396.1; WP_001298299.1